EFEKTIVITAS PEMBERIAN EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi Linn) TERHADAP PENURUNAN LEUKOSIT PADA MENCIT INFEKSI NIFAS

Abstract

Postpartum infection is one of the causes of maternal death in Indonesia. Stapylococcus aureus is an invasive gram-positive bacterium and causes various infections. Widespread bacterial resistance to antibiotics, encouraged in the search for alternative steps with the provision of natural antibacterial ingredients. Flavonoids, saponins, tannins are active ingredients contained in the leaves of starfruit which can be used as antibacterial. The purpose of this study was to determine the effect of giving starfruit leaf extract (Averrhoa bilimbi Linn) to the decrease in the number of leukocytes in mice with puerperal infection. The research method used is true experiment posttest only control group design. Research replication of mice was 24 and grouped into 4 namely control, group P1 (extract of belimbing wuluh leaf dose 100 mg / kg / BB), group P2 (extract of belimbing wuluh leaf dose 200 mg / kg / BB) and group P3 (leaf extract starfruit wuluh dose of 400 mg / kg / BB). The measurement of leukocyte count was carried out using the Hematology Analyzer Sysmax KX-21. The results showed that there was a significant decrease in the number of leukocytes in the treatment group giving extracts of wuluh starfruit leaves 100 mg / kgBB, 200 mg / kgBB and 400 mg / kgBB. Provision of leaf starfruit extract has been shown to reduce leukocytes in mice with puerperal infection. Therefore the extract of starfruit leaves can be beneficial to increase the body's immunity so that no infection occurs during the puerperium.