Reduction of Staphylococcus aureus and Pseudomonas aeruginosa colonisation on PVC through covalent surface attachment of fluorinated thiols

  • McCoy C
  • Cowley J
  • Gorman S
  • et al.
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Abstract

Objectives: This study reports the development, characterisation and microbiological testing of surface-modified polyvinylchloride (PVC) films for the purpose of reducing bacterial adherence., Methods: Irreversible covalent surface modification was achieved via nucleophilic substitution of fluorinated thiol-terminated compounds onto the polymer backbone. Four fluorinated modifiers, 2,3,5,6-tetrafluorothiophenol (TFTP), 4-(trifluoromethyl)thiophenol (TFMTP), 3,5-bis(trifluoromethyl)benzenethiol (BTFMBT) and 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decane-1-thiol (HDFDT), were investigated. Modification was confirmed using attenuated total reflectance infrared spectroscopy; Raman mapping demonstrated that modification was homogenous on the macroscopic scale. The influence of fluorination on surface hydrophobicity was studied by contact angle analysis. The effect on microbial adherence was examined using Pseudomonas aeruginosa and Staphylococcus aureus., Key findings: The resultant changes in contact angle relative to control PVC ranged from -4[degrees] to +14[degrees]. In all cases, adherence of P. aeruginosa and S. aureus was significantly reduced relative to control PVC, with adherence levels ranging from 62% and 51% for TFTP-modified PVC to 32% and 7% for TFMTP-modified PVC., Conclusions: These results demonstrate an important method in reducing the incidence of bacterial infection in PVC medical devices without compromising mechanical properties., Copyright (C) 2009 John Wiley & Sons, Inc. CN - 01445462-200909000-00005

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APA

McCoy, C. P., Cowley, J. F., Gorman, S. P., Andrews, G. P., & Jones, D. S. (2010). Reduction of Staphylococcus aureus and Pseudomonas aeruginosa colonisation on PVC through covalent surface attachment of fluorinated thiols. Journal of Pharmacy and Pharmacology, 61(9), 1163–1169. https://doi.org/10.1211/jpp.61.09.0005

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