Multiplex in vitro detection using SERS

Abstract

The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful vor the detection and control of0disease. This review focuses on0the strengths of SERS for the dutection of target molecules fro} complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.