Synthesis and characterization of a linker for primary amines used in the solid phase organic synthesis of spermidine

Abstract

A linker resin for the synthesis of functionalized spermidine in good yield is described, along with its characterization by infrared (IR), 13C solid-state nuclear magnetic resonance with cross polarization and magic angle spinning (13C CPMAS NMR) and 1H high resolution magic angle spinning nuclear magnetic resonance (1H HRMAS NMR. This linker has been regenerated after cleavage of spermidine and re-used without loss of efficiency. © 2011 Sociedade Brasileira de Química.