Fungal Metabolites. XVI.1) Structures of New Peptaibols, Trichokindins I—VII, from the Fungus Trichoderma harzianum

Abstract

New peptaibols, trichokindins I—VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca2+-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells. © 1994, The Pharmaceutical Society of Japan. All rights reserved.