Evaluation of synergistic medicinal efficacy of four alkaloidic compounds isolated from Iraqi Allium porrum seeds against staphylococcus aureus bacteria

Abstract

Medicinal plants are necessary benefit natural sources for chemical production of different therapies from secondary metabolism .Allium porrum is considered as one of sources of foods and drugs at the same time . So the current work focused on isolation and characterization of four alkaloids from seeds of this plant . These compounds are 2-piperidinone, 2-pyrrolidinone-4-methyl, adenosine -2-deoxy–N- methyl –N- (triflouro acetyl) and maymarsine by using Gas Chromatography – Mass Spectroscopy (GC-MS) technique. The medicinal activity was achieved to investigate and evaluate the synergistic action of the mixture of the four alkaloidic compounds towards Staphylococcus aureus pathogen . The concentrations of alkaloidic mixture were prepared with values equal to 50,100,125,150,200,250,300,375,400 and 500 mg/ml and they revealed inhibition zones with diameters represented by 31,31,32,35,35,37,41,43,43and 45 mm . So the mixture of the four alkaloidic compounds can be used as natural therapy to treat various inflammatory caused by this pathogenic bacteria .