Childhood Nephrotic Syndrome in Ilorin

Abstract

A cohort of 17 children (12M:5F), aged 3-16 years, with nephrotic syndrome seen at the University of Ilorin Teaching Hospital, Ilorin, between January 1995 and December 1998 were studied. Renal biopsies were performed in eight patients. Five (63 per cent) of the biopsies showed focal mesangial proliferative glomerulonephritis while one each showed minimal change, membranoproliferative, and mesangial proliferative glomerulonephritis on light microscopy. Only three (17.6 per cent) of the 17 patients were steroid responsive, while six (35 per cent) were steroid resistant. The predominant histological finding in the steroid resistant cases was focal mesangial proliferative lesion. Case fatality was 12 per cent from two deaths. The histopathological findings in the two patients who died of end-stage renal disease, consisted of minimal change lesion and membranoproliferative glomerulonephritis, respectively. Nigerian Journal of Paediatrics 2001; 28:68. pp. 68-72