Exosomes expand the sphere of influence of Eph receptors and ephrins

Abstract

Membrane-anchored Eph receptors and ephrins represent a ubiquitous intercellular communication system that typically engages at sites of cell-cell contact to initiate bidirectional signaling. Gong et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201601085) show that cells can deploy the EphB2 receptor on exosomes to activate ephrinB signaling and collapse the growth cones of distant neurons.