Recent trends insirna delivery for treatment of colorectal cancer

Abstract

Colorectal cancer (CRC) is the third most widespread cancer in the world. Currently, chemotherapy is an effective treatment for CRC but acquired multidrug resistance (MDR) due to active drug efflux pumps is the major challenge with chemotherapy. Recently, siRNA (small interfering RNA) therapeutics has getting more attention to overcome the MDR in cancer and other diseases. siRNA is a 21-23 base pair double-stranded RNA having the ability to silence specific genes at the post-transcriptional level. But, clinical practice of siRNA delivery has a limitation due to enzymatic degradation by serum nucleases resulting in poor stability, poor cellular uptake at target site. Nowadays, the development of various nanocarriers for efficient delivery of siRNA is the most challenging and rapidly growing research area. In this review we have summarized, the potential of various nanocarriers such as polymeric nanoparticles, lipid-based nanoparticles, inorganic nanoparticles, layered double hydroxide nanoparticles for siRNA delivery in colorectal cancer treatment.