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A pH- and ionic strength-responsive polypeptide hydrogel: Synthesis, characterization, and preliminary protein release studies

Journal of Biomedical Materials Research (1997) 47(4) 595-602
DOI: 10.1002/(SICI)1097-4636(19991215)47:4<595::AID-JBM17>3.0.CO;2-I
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Abstract

A novel polypeptide hydrogel was synthesized by crosslinking poly(L-glutamic acid) (PLG) with poly(ethylene glycol) (PEG). The hydrogel was found to be highly hydrophilic, and the extent of swelling varied with pH, increasing at higher ionization of the PLG. Rapid de-swelling of the hydrogel facilitated lysozyme release.

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Markland, P., Zhang, Y., Amidon, G. L., & Yang, V. C. (1997). A pH- and ionic strength-responsive polypeptide hydrogel: Synthesis, characterization, and preliminary protein release studies. Journal of Biomedical Materials Research, 47(4), 595–602. https://doi.org/10.1002/(SICI)1097-4636(19991215)47:4<595::AID-JBM17>3.0.CO;2-I

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