Use of equine-origin antitoxins in piglets prior to exposure to mitigate the effects of Clostridium difficile infection - A pilot study

Abstract

Administration to newborn pigs of an oral or intraperitoneal dose of equine-origin Clostridium difficile antitoxin 4 hours before orogastric inoculation with a swine-origin C difficile field isolate resulted in lower histopathology scores 72 hours post challenge than in pigs receiving no antitoxin (P < .05).