SYNTHESIS AND IN-VITRO ANTIMICROBIAL ACTIVITY OF PYRIMIDINE DERIVATIVES

Abstract

In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the 4-position is described. These unreported compounds are obtained starting from commercially available dehydroacetic acid (DHA), aromatic aldehydes and S-benzylisothiouronium chloride (SBT). A series of compounds (3a-j) were prepared and tested for their antimicrobial activity. These synthesized compounds showed mild activity against gram +ve bacteria and very less activity against gram -ve bacteria. Compounds 3b, 3i, 3j showed mild activity against gram +ve Bacillus subtilis bacteria while against gram -ve Pseudomonas aeruginosa compound 3i showed minor activity.