Recent Progresses in the Synthesis of Solanoeclepin A

Abstract

Solanoeclepin A, first isolated from potato roots (Solanaceae Juss.) by Mulder et al., is an highly active hatching stimulant (0.3 g per hectare) of potato cyst nematode (PCN, Globodera rostochiensis and G. pallida) which causes severe damage to potato crops. Its complex chemical structure belongs to a rearranged tetranortriterpene and possesses extremely unique skeleton. Based on the known general biosynthesis of tetranortriterpenoids and Prof. Corey's biomimetic synthesis of glycinoeclepin, a plausible biosynthetic pathway of solanoeclepin A is proposed. A schematic review on the synthetic studies towards solanoeclepin A is provided.