Primary cutaneous gamma-delta T-Cell lymphoma

Abstract

Primary cutaneous gamma-delta T-cell lymphoma is a highly aggressive skin lymphoma and typically involves the subcutaneous fat, deep dermis, as well as epidermis. This disease is rare and typically present with systemic symptoms such as hemophagocytic syndrome and B symptoms. This T-cell lymphoma has a mature cytotoxic T-cell phenotype but typically lacks CD5 as well as CD4 and CD8. More importantly, expression of the gamma-delta T-cell receptor (TCR) is present in most cases. The latter finding has been useful in distinguishing more indolent T-cell lymphoma such as subcutaneous panniculitis like T-cell lymphoma and reactive conditions.