Pengaruh Pemberian Ekstrak Etanol Daun Mahoni (Swietenia macrophylla) Terhadap Luka Sayat Pada Kelinci (Oryctolagus cunicullus)

Abstract

An incision was an injury caused by direct contact of the body with sharp objects. Incisions not only cause skin damage, but can also affect the body's systems. Therefore, incisions require special attention. Mahogany leaves (Swietenia macrophylla) were a medicinal plant which was known to contain compounds that play a role in wound healing, such as flavonoids, saponins, tannins and alkaloids. This study aims to determine the ethanol extract of mahogany leaves has an effect on wound healing in rabbits. Mahogany leaf extract was prepared by maceration using 96% ethanol solvent. The wound healing test in rabbits were divided into five treatment groups, namely the positive control group, the negative control group (coconut oil), and three test groups given ethanol extract of mahogany leaves with a concentration of 5%, 10% and 20%. Making an incision using a scalpel which is sliced into the back of the rabbit for 5 incisions. Rabbits were observed every day for one week with statistical analysis One Way ANOVA test. The ethanol extract of mahogany leaves with a concentration of 5% 10% and 20% had the effect of wound healing at a concentration of 5%, respectively (11, 22 ± 0.84)%, 10% (15.94 ± 0.70)%, and 20 % (21.46 ± 1.49)%, while the positive control was (22.76 ± 1.30)%. There was a statistically significant difference in the healing power of cuts in rabbits. Mahogany leaf ethanol extract can be used as wound healing in rabbits.