Treatment intensification for locally advanced rectal cancer: Impact on pathological complete response and outcomes

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Abstract

Aim: Pathological complete response (pCR) and clinical outcomes [overall survival (OS), disease-free survival (DFS), locoregional control (LC)] were evaluated in a single-institution experience of different schedules of neoadjuvant chemoradiotherapy (CRT) for patients with locally advanced rectal cancer (LARC). Patients and Methods: Data for 322 patients with LARC were retrospectively analyzed. pCR was evaluated according to Mandard tumor regression grade (TRG). The Kaplan-Meier method was used to estimate OS, DFS and LC. Results: Three hundred and three (94.1%) patients underwent surgery. pCR was observed in 81 patients (26.7%), with TRG1-2 rate of 41.8%. The 5- and 10-year OS, DFS and LC rates were 82.5%±2.5% and 65.5%±3.8%, 81.2%±2.4% and

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Tommaso, M. D. I., Rosa, C., Caravatta, L., Augurio, A., Borzillo, V., Santo, S. D. I., … Genovesi, D. (2020). Treatment intensification for locally advanced rectal cancer: Impact on pathological complete response and outcomes. In Vivo, 34(3), 1223–1233. https://doi.org/10.21873/invivo.11896

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