749 Human Immunoglobuline Role in Treatment of Idiopathic Thrombocytopenic Purpura

Abstract

Introduction Idiopathic thrombocytopenic purpura is a disorder, in which immune system destroys platelets, which are necessary for blood clotting. ITP persons have a very low platelet count. ITP appears when the immune system products antibodies against platelets. This disorder attacks equally boys and girls. Objective The purpose of study was to present cases and treatment of the patients who are hospitalized in Pediatric Clinic in Prishtina at the hematology-Oncology unit. Materials and Methods In this study there are included 24 cases that are hospitalized in chemato - Oncology unit during 2011 and their treatment. The diagnose is made based on anamnesis, clinical examinations, laboratory checks, biochemistry, ultrasound examinations, and bone marrow biopsy. Results 7 cases (29.1%)were treated with human immunoglobulin, while 17 cases (69.9%) were treated with steroids. Immunoglobulin treatment last for 5 days. The second day of treatment with human immunoglobulin the average platelet count increase was 30% higher, while in the fifth day platelet count arrived normal values. In patient treated with steroids platelet count began to rise after one week of treatment., in most cases platelet coun was normal after two weeks of treatment. Conclusion Immunoglobulin therapy is a very efficient therapy in acute idiopathic thrombocytopenia especially in serious and possibly fatal complications such as gastrointestinal and intracranial bleeding.