Triterpenic derivatives of Achillea alexandri-regis Bornm. & Rudski

Abstract

Investigation of the aerial parts of Achillea alexandri-regis led to the identification of 19 chemical constituents: twelve 3-O-fatty acid esters of triterpene alcohols arnidiol (1-4), maniladiol (5-8) and 16β-hydroxylupeol (9-12), α-amyrin, β-amyrin, β-sitosterol, 3,4-O-dicaffeoyl quinic acid, cinnamic acid, pinoresinol-β-D-glucoside and rutin. Among them, compounds 3, 4, 8, 11 and 12 are new natural products. The structures of all compounds have been elucidated on the basis of their spectral and chemical data. © 2004 Pharmaceutical Society of Japan.