Natural Killer Cell Leukemia: Diagnosis, Pathogenesis and Treatment

Abstract

Natural Killer(NK) cell nenoplasm is heterogeneous disease group. In the latest World Health Organization(WHO) classification of tumors of hematopoietic and lymphoid tissue(2008), disease entities considered as NK cell deviation are 1) Aggressive NK cell leukemia (ANKL), 2) NK cell lymphoblastic leukemia/lymphoma, 3) Extranodal NK/T-cell lymphoma, nasal. While several NK related diseases are proposed and investigated actively, optical treatment of NK cell neoplasms remains uncertain. However, several new chemoagents and transplantation are now in progress.