Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell

Abstract

Background: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. Objective: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. Methods: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-a, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. Results: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-a, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. Conclusion: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-a, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.