Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux-en-Y gastric bypass

Abstract

Objective Soluble CD163 (sCD163) is a new marker of obesity-related metabolic complications. sCD163 and CD163 mRNA were investigated in relation to the fat distribution at baseline and 12 months after Roux-en-Y gastric bypass (RYGB). Methods Thirty-one obese subjects (BMI: 42.3-±-4.7 kg/m 2) were enrolled. Subcutaneous (SAT) and visceral adipose tissue (VAT) volume were determined by MRI, intrahepatic lipid content (IHL) by MR-spectroscopy, and body composition by DXA. Fasting blood samples and adipose tissue samples were obtained, and ELISA and RT-PCR were performed. Results RYGB-induced weight loss (36-±-11 kg) was accompanied by a significant reduction in sCD163 (2.1-±-0.8 mg/l vs. 1.7-±-0.7 mg/l), SAT, VAT, and IHL (all, P-