Thrombotic microangiopathy associated with bortezomib treatment in a patient with relapsed multiple myeloma

Abstract

Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) describe microvascular occlusive disorders characterized by thrombocytopenia due to increased platelet aggregation and fragmenta¬tion hemolysis. We report here what to our knowledge is the second case of TTP/HUS associated with bortezomib treatment.