N-acylation of sulfonamides using N-acylbenzotriazoles

Abstract

Reactions of sulfonamides with readily available N-acylbenzotriazoles (RCOBt, where R is an aryl, heteroaryl, or N-Cbz-protected-α-amino(alkyl) group), in the presence of NaH, produced N-acylsulfonamides in 76-100% yields. The ability to utilize N-acylbenzotriazoles for which the corresponding acid chlorides are not easily prepared, may be especially advantageous.