Dye-Cucurbit[n]uril complexes as sensor elements for reliable pattern recognition of biogenic polyamines

Abstract

The host-guest complexes between commercially available fluorescence dyes and cucurbit[n]urils (CB[n], n = 6, 7 and 8) were exploited as multiple sensor elements to provide arrays for sensing biogenic amines using principal component analysis (PCA). Since the sensor elements respond differently to each amine, the array generates distinct patterns of fluorescence changes for each amine. We analyzed these results using PCA to allow precise discrimination of individual biogenic amines. This result demonstrated the great potential of these host-guest complexes as useful sensor elements for biogenic molecules, which may be useful to develop a diagnostic tool for diseases including cancers.