Multithreshold Segmentation and Machine Learning Based Approach to Differentiate COVID-19 from Viral Pneumonia

Abstract

Coronavirus disease (COVID-19) has created an unprecedented devastation and the loss of millions of lives globally. Contagious nature and fatalities invariably pose challenges to physicians and healthcare support systems. Clinical diagnostic evaluation using reverse transcription-polymerase chain reaction and other approaches are currently in use. The Chest X-ray (CXR) and CT images were effectively utilized in screening purposes that could provide relevant data on localized regions affected by the infection. A step towards automated screening and diagnosis using CXR and CT could be of considerable importance in these turbulent times. The main objective is to probe a simple threshold-based segmentation approach to identify possible infection regions in CXR images and investigate intensity-based, wavelet transform (WT)-based, and Laws based texture features with statistical measures. Further feature selection strategy using Random Forest (RF) then selected features used to create Machine Learning (ML) representation with Support Vector Machine (SVM) and a Random Forest (RF) to make different COVID-19 from viral pneumonia (VP). The results obtained clearly indicate that the intensity and WT-based features vary in the two pathologies that are better differentiated with the combined features trained using SVM and RF classifiers. Classifier performance measures like an Area Under the Curve (AUC) of 0.97 and by and large classification accuracy of 0.9 using the RF model clearly indicate that the methodology implemented is useful in characterizing COVID-19 and Viral Pneumonia.