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Nanoscale label-free bioprobes to detect intracellular proteins in single living cells

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Abstract

Fluorescent labeling techniques have been widely used in live cell studies; however, the labeling processes can be laborious and challenging for use in non-transfectable cells, and labels can interfere with protein functions. While label-free biosensors have been realized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and in living cells has not been found. Here we present the first demonstration of label-free detection of intracellular p53 protein dynamics through a nanoscale surface plasmon-polariton fiber-tip-probe (FTP).

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Hong, W., Liang, F., Schaak, D., Loncar, M., & Quan, Q. (2014). Nanoscale label-free bioprobes to detect intracellular proteins in single living cells. Scientific Reports, 4. https://doi.org/10.1038/srep06179

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