APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress.
CITATION STYLE
Cescon, D. W., & Haibe-Kains, B. (2016). DNA replication stress: A source of APOBEC3B expression in breast cancer. Genome Biology, 17(1). https://doi.org/10.1186/s13059-016-1069-y
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