Acute toxicity tests of metrizamide

Abstract

The intravenous toxicity of metrizamide is very low. In mice the for male mice and for female mice-is about twice as high as the LD of diatrizoate, metrizoate and iothalamate, which in our laboratory have been found to be 9-10. Also in rats metrizarnide has a lower intravenous toxicity than the vascular media in common use. In rabbits we have found metrizamide to be superior to iothalamate which in our tests has about the same LD;;o as diatrizoate and rnetrizoate. The advantage of metrizamide in suboccipital injection in mice is even greater, the of metrizamide being more than 1 500 mg I/kg, while the best of the ionic water-soluble media, meglumine iocarmate, has an LD50 of 350 mg. The intraperitoneal toxicity is not different from that of meglumine iothalamate. © 1973, The Foundation Acta Radiologica. All rights reserved.