Synthesis of mono- and N,N-disubstituted ureas

Abstract

Benzotriazole-1-carboxamide is a new efficient reagent for the preparation of mono- and N,N-disubstituted ureas. The title ureas 3 were obtained from benzotriazole-1-carboxamide with primary and secondary aliphatic amines and p-anisidine under mild conditions with simple purification in isolated yields of 61-96%. The procedure developed is suitable for solid-phase work.