Explainable CNN for brain tumor detection and classification through XAI based key features identification

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Abstract

Despite significant advancements in brain tumor classification, many existing models suffer from complex structures that make them difficult to interpret. This complexity can hinder the transparency of the decision-making process, causing models to rely on irrelevant features or normal soft tissues. Besides, these models often include additional layers and parameters, which further complicate the classification process. Our work addresses these limitations by introducing a novel methodology that combines Explainable AI (XAI) techniques with a Convolutional Neural Network (CNN) architecture. The major contribution of this paper is ensuring that the model focuses on the most relevant features for tumor detection and classification, while simultaneously reducing complexity, by minimizing the number of layers. This approach enhances the model’s transparency and robustness, giving clear insights into its decision-making process through XAI techniques such as Gradient-weighted Class Activation Mapping (Grad-Cam), Shapley Additive explanations (Shap), and Local Interpretable Model-agnostic Explanations (LIME). Additionally, the approach demonstrates better performance, achieving 99% accuracy on seen data and 95% on unseen data, highlighting its generalizability and reliability. This balance of simplicity, interpretability, and high accuracy represents a significant advancement in the classification of brain tumor.

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Iftikhar, S., Anjum, N., Siddiqui, A. B., Ur Rehman, M., & Ramzan, N. (2025). Explainable CNN for brain tumor detection and classification through XAI based key features identification. Brain Informatics, 12(1). https://doi.org/10.1186/s40708-025-00257-y

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