P08.70 Prognostic and predictive factors in primary Glioblastoma Multiforme WHO grade IV patients with resection: A single-institution study

Abstract

Abstract Background: Patients with GBM continue to have a dismal prognosis, with a median survival of about 12 months. Methods: This prospective population-based study is focused on the relation among the selected gene aberrations and overall survival of primary Glioblastoma Multiforme patients only with resection. We collected clinical data of 140 patients treated in our hospital from Jully 2006 to June 2014. All tumour samples were submitted to histologic analysis and were investigated for the aberrations of TP53, EGFR1, PTEN, MDM2, RB1, CCND1, BCR, 9p21 (CDKN2A, p16), 10p11, 19q13, 1p36, IDH1 mutation, and MGMT promoter methylation. Results: The younger age, Karnofsky score an chemoradiotherapy (14.6 vs 5.3 months in radiotherapy alone) at diagnosis was a positive and smoking was a negative prognostic factor. Temporal lobe tumour origin was associated with a shorter period of Performance free status in the group with chemoradiotherapy. Relation with OS according to univariate Cox regression model: p53 high copy number (HCN), CCND1 HCN, 10p11HCN and partly MGMT promoter methylation were linked to prolonged OS. Cox proportional regression models for survival revealed that TP53 HCN was associated with a prolonged OS of all patients and the chemoradiotherapy group. CCND1 HCN, 10p11HCN and partly MGMT promoter methylation significantly extended OS in the group with chemoradiotherapy. The effect of these gene changes on OS was reduced in the group of all patients. Conclusion: Author made the efforts to gain clinical and genetic factors, which easily usable in the clinical practice. Contrary literature data, there were confirmed TP53, CCND1 as predictive and prognostic factors.