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Single-molecule arrays for ultrasensitive detection of host immune response to dengue virus infection

Journal of Clinical Microbiology (2015) 53(5) 1722-1724
DOI: 10.1128/JCM.03487-14
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Abstract

Dengue virus serotype 2-positive plasma was applied to two indirect single-molecule arrays (Simoas) for the detection of anti-dengue virus IgG and IgM. The Simoas were 1,000 and 10,000 times more sensitive than enzyme-linked immunosorbent assays (ELISAs) for the detection of IgG and IgM, respectively. Using Simoas, serology may be used for the detection of dengue virus infection in the acute phase.

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Gaylord, S. T., Abdul-Aziz, S., & Walt, D. R. (2015). Single-molecule arrays for ultrasensitive detection of host immune response to dengue virus infection. Journal of Clinical Microbiology, 53(5), 1722–1724. https://doi.org/10.1128/JCM.03487-14

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