Expansive remodeling is a response of the plaque-related vessel wall in aortic roots of apoE-deficient mice: An experiment of nature

Abstract

Objective - In the present study, we (1) evaluated the apolipoprotein E-deficient (apoE-/-) mouse aortic root as a model for expansive remodeling in atherosclerosis and (2) examined whether remodeling at this site was due to dilation of the vessel wall beneath or flanking the plaque. Methods and Results - Plaque area and length of the internal elastic lamina (IEL) weremeasured in aortic roots of apoE-/- mice at 11 weeks, 6 months, and 13 months of age. Expansive remodeling, indicated by IEL lengthening exceeding that of normal growth in wild-type C57BL/6 mice, was evident at 6 months of age and showed overcompensation (luminal enlargement) by 13 months of age. When the left coronary (LC), right coronary (RC), and noncoronary (NC) sinuses of the aortic root were looked at individually, remodeling was located to the LC at 6 months of age and to the LC and RC at 13 months of age. The remodeling response was closely related to local plaque area but unrelated to plaque formation in flanking sinuses. Conclusions - The aortic root of the apoE-/- mouse features a consistent remodeling response. In this model, expansive remodeling was a strictly local response of the plaque-related vessel wall.