ANTI INFLAMMATORY, ANTI OXIDANT AND ANTI MICROBIAL ACTIVITY OF A NEW HERBAL EYE DROP

Abstract

Many antibiotic and steroid preparations are available for the management of Ophthalmic disorders. However prolonged use may have potential side effects. Ayurvedic Science has described many medicinal plants for treatment of ocular disorders. The aim of this study was to develop a new poly herbal formula with good anti inflammatory, anti oxidant and anti bacterial activity. A new poly herbal formula was developed from the aqueous distillates of a mixture of herbs like Padmakam (Caesalpina sappan), Jati (Jasminum grandiflorum), Tulsi (Ocimum sanctum) and Durva (Cynodon dactylon) which have proven anti-inflammatory, antioxidant and antibacterial activities. The distillate was mixed with Saindhava lavana (Rock Salt), Honey, Rose water and Bhimseni kapur (Borneol). The anti-inflammatory activity of this formulation was evaluated in Turpentine liniment induced ocular inflammation in rabbits for chemosis, eye discharge and conjunctival congestion. Results for the biological evaluation of the formula showed that its anti inflammatory activity was comparable to that of standard betamethasone. The formula also exhibited good antioxidant potential and which was comparable to that of curcumin. It showed antimicrobial activity and the zone of inhibition against Staphylococcus aureus and Escherichia coli that is comparable to Gentamycin eye drops.