New Strategy against COVID-19: L-Serine Doped QDs for Fast Detection of COVID-19 and Blocking of S-Protein

Abstract

To detect COVID-19, the reverse transcription-polymerase chain reaction (RT-PCR) is usually used but there is a number of faulty tests or an inexact diagnostic, especially in the primordial period of infection. In this regard, the optical response of hybrid quantum dots (QDs): L-serine is presented for the first time as a new and rapid method of detection. QDs were further conjugated with anti-infectious viruses’ antibodies. The detection of a target analyte is increased due to the fact that the final formed hybrid system is exposed to doses of L-serine optically active. QDs acts as L-Serine’s host. This last will trap the virus and emerges less/high photoluminescence (PL) response depending on the L-serine, virus, and doping concentrations. Such rapid optical treatment will inform us of the infection state faster and more efficiently than ELISA tests. The fluorescence properties of the new hybrid system permit a control of coronavirus with a limit of detection LOD ∼80 EID/50 μ l thanks to families of clusters induced by L-serine’s molecules. Families of L-serine clusters with inhomogeneous densities can block the S-protein in COVID-19. Moreover, the detection can be issued by trapping the virus with the same dopant.