Bacteremic disseminated tuberculosis in sub-Saharan Africa: A prospective cohort study

Abstract

Background. Disseminated tuberculosis is a major health problem in countries where generalized human immunodeficiency virus (HIV) infection epidemics coincide with high tuberculosis incidence rates; data are limited on patient outcomes beyond the inpatient period. Methods. We enrolled consecutive eligible febrile inpatients in Moshi, Tanzania, from 10 March 2006 through 28 August 2010; those with Mycobacterium tuberculosis bacteremia were followed up monthly for 12 months. Survival, predictors of bacteremic disseminated tuberculosis, and predictors of death were assessed. Antiretroviral therapy (ART) and tuberculosis treatment were provided.Results.A total of 508 participants were enrolled; 29 (5.7) had M. tuberculosis isolated by blood culture. The median age of all study participants was 37.4 years (range, 13.6-104.8 years). Cough lasting >1 month (odds ratio [OR], 13.5; P 1 month (OR, 7.8; P =. 001), weight loss of >10 (OR, 10.0; P =. 001), lymphadenopathy (OR 6.8; P =. 002), HIV infection (OR, undefined; P