Development and validation of a nomogram-based risk prediction model for carbapenem-resistant Klebsiella pneumoniae in hospitalized patients

Abstract

We established a nomogram scoring system that incorporates four key risk factors: prior carbapenem exposure, prior β-lactams–β-lactamase inhibitor combination (BLBLI) exposure, prior intensive care unit (ICU) stay, and prior mechanical ventilation. This nomogram demonstrated strong discriminatory power, excellent calibration, and significant clinical utility. This study highlights the critical risk factors associated with hospital-acquired carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, providing valuable insights for clinicians to identify high-risk patients.