Bayesian generalized linear low rank regression models for the detection of vaccine-adverse event associations

Abstract

We propose a generalized linear low-rank mixed model (GLLRM) for the analysis of both high-dimensional and sparse responses and covariates where the responses may be binary, counts, or continuous. This development is motivated by the problem of identifying vaccine-adverse event associations in post-market drug safety databases, where an adverse event is any untoward medical occurrence or health problem that occurs during or following vaccination. The GLLRM is a generalization of a generalized linear mixed model in that it integrates a factor analysis model to describe the dependence among responses and a low-rank matrix to approximate the high-dimensional regression coefficient matrix. A sampling procedure combining the Gibbs sampler and Metropolis and Gamerman algorithms is employed to obtain posterior estimates of the regression coefficients and other model parameters. Testing of response-covariate pair associations is based on the posterior distribution of the corresponding regression coefficients. Monte Carlo simulation studies are conducted to examine the finite-sample performance of the proposed procedures on binary and count outcomes. We further illustrate the GLLRM via a real data example based on the Vaccine Adverse Event Reporting System.