Abstract
Hyperosmolar agents for intracranial hypertension started to be used in the early 20th century and they still are an important component of the management of the treatment of patients with cerebral edema. Among these, mannitol is the most commonly used intraoperative hypertonic solution in patients undergoing brain surgery. In this paper, we discuss the current evidence for the use of mannitol in neurosurgery and neuro-ophthalmology, with focuses on its pharmacokinetics and its main physiologic effects.
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Turliuc, M. D., Cucu, A. I., Costachescu, B., Tudor, R. M., Papacocea, T., Bogdanici, C. M., … Costea, C. F. (2019). The use of mannitol in neurosurgery and neuro-ophthalmology. Cellulose Chemistry and Technology, 53(7–8), 625–633. https://doi.org/10.35812/CelluloseChemTechnol.2019.53.61
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