Pancreatic acinar cell nuclear factor κb activation because of bile acid exposure is dependent on calcineurin

Abstract

Background: Bile acids cause activation of NF-κB and lead to injury in pancreatic acinar cells, but the mechanism is unknown. Results: Pharmacologic and genetic inhibition of calcineurin reduces bile acid-induced NF-κB activation and PKC-κ translocation. Conclusion: Calcineurin facilitates bile-induced NF-κB activation. The mechanism is at the level of PKC activation. Significance: We have identified a novel mechanism by which bile acids facilitate NF-κB activation in pancreatic acinar cells. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.