Transcriptomic studies routinely measure expression levels across numerous conditions. These datasets allow identification of genes that are specifically expressed in a small number of conditions. However, there are currently no statistically robust methods for identifying such genes. Here we present SpeCond, a method to detect condition-specific genes that outperforms alternative approaches. We apply the method to a dataset of 32 human tissues to determine 2,673 specifically expressed genes. An implementation of SpeCond is freely available as a Bioconductor package at http://www.bioconductor.org/packages/release/bioc/html/SpeCond.html. © 2011 Cavalli et al.; licensee BioMed Central Ltd.
CITATION STYLE
Cavalli, F. M. G., Bourgon, R., Huber, W., Vaquerizas, J. M., & Luscombe, N. M. (2011). SpeCond: A method to detect condition-specific gene expression. Genome Biology, 12(10). https://doi.org/10.1186/gb-2011-12-10-r101
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