Male Breast Cancer: Case Studies and Literature Review

Abstract

Male breast cancer is a rare disease. In Tunisia, it represents 1% of all breast cancers and 1.6% of Male neoplasia. This work is a retrospective study about 5 male patients with breast cancer, treated in the department of medical oncology at Fattouma Bourguiba University Hospital of Monastir (Tunisia) during a period of 3 years from March 2013 to March 2016. Results showed that: in-vasive ductual carcinoma was the histological type found in all cases; the Her 2 neu was not overexpressed in all cases; hormone receptors were positive in all patients. Two patients had a locally advanced disease. Two patients were diagnosed with metastatic disease; pulmonary and bone metastases. Three patients who were diagnosed with no metastatic disease have had a mastectomy with Axillary lymph node dissection. Adjuvant chemotherapy was administered in two patients. Loco regional radiotherapy was performed in three patients. Tamoxifen-based hormone therapy was administered in three patients. Two patients were treated with palliative chemotherapy. One patient received two lines of chemotherapy with a global survival of 16 months, while the other received only one line of palliative chemotherapy with a global survival of 2 months. One patient received palliative hormone therapy type Tamoxifen with progression free survival of 7 months. Three patients who received cura-tive treatments are in remission of their disease. To conclude male breast cancer is a rare disease with multiple and varied risk factors. It is similar in its clinical, histological and prognostic characteristics to breast cancer in women but also has different characteristics.