Hypoglycemic Effect of the Rhizomes of Ophiopogonis Tuber In Normal and Diabetic Mice

Abstract

The hypoglycemic effect of the rhizomes of Ophiopogonis Tuber (Liliaceae) was investigated in normal and streptozotocin-induced diabetic mice. the n-butanol extract of rhizomes of Ophiopogonis Tuber (BM) (100 mg/kg) reduced the blood glucose of normal mice from 201±13 to 151±7 mg/100 ml 4h after intraperitoneal administration (p<0.054), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 590±28 to 470±37 mg/100 ml under similar conditions (p<0.05). BM also tended to suppress epinephrine-induced hyperglycemia in mice. We concluded that the hypoglycemic effect of BM does not alter the insulin concentration. © 1995, The Pharmaceutical Society of Japan. All rights reserved.