Forced vital capacity and forced expiratory volume in six seconds as predictors of reduced total lung capacity

Abstract

The present study aims to derive guidelines that identify patients for whom spirometry can reliably predict a reduced total lung capacity (TLC). A total of 12,693 lung function tests were analysed on Caucasian subjects, aged 18-70 yrs. Restriction was defined as a reduced TLC. Lower limits of normal (LLN) for TLC were obtained from the European Respiratory Society recommended reference equations. Reference equations from the National Health and Nutrition Examination Survey III were used for forced vital capacity (FVC) and forced expiratory volume in six seconds (FEV6). The performance of FVC and FEV6 to predict the presence of restriction was studied as follows: 1) using two-by-two (2 x 2) tables; and 2) by logistic regression analysis. Both analyses were performed in obstructive (defined as forced expiratory volume in one second (FEV1)/FVC or FEV1/FEV6 <55% predicted (males) or <40% pred (females). Restriction can be ruled out if FVC or FEV in six seconds is >100% pred (males) or >85% pred (females). In obstructive patients, spirometry cannot reliably diagnose a concomitant restrictive defect, but it can rule out restriction for patients with forced vital capacity or forced expiratory volume in six seconds >85% pred (males) or >70% pred (females). Copyright©ERS Journals Ltd 2008.