Reduced Minimum Inhibitory Concentration of Antibiotics Associated with DT 104 Phage Type of Salmonella Enterica Serovar Typhimurium

Abstract

There has been worldwide emergence of a multi-drug resistant S. typhimurium phage type DT104. It is reported to be resistant to five antibiotics viz., ampicillin, chloramphenicol, streptomycin, sulphonamide and tetracycline (ACSSuT) and a major health concern for human and animals alike. A study was undertaken to illuminate the MIC levels of five antibiotics among Indian isolates of S. typhimurium. Examination of 100 strains of S. typhimurium revealed that all the strains were sensitive to chloremphenicol and streptomycin and 95{%} of tested strains were sensitive to ampicilline. However, sulfisoxazole and tetracycline expressed resistance of 93{%} and 57{%}, respectively. The MIC values of all the antibiotics determined in this study were much below the break point except for one isolate, which showed-MIC value of {>}240 micro g/ml for sulfisoxazole. The study provides valuable information on the MIC value of S. typhimurium and it appears that this organism circulating in India have not yet acquired resistance against most of these antibiotics. Judicious use of these antibiotics in human and veterinary practice and regular monitoring is required to keep a check on the situation.