Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor

Abstract

Monokine-stimulated endothelial cells are known to produce both burst- and colon-stimulating activities, but neither the nature of the monokine nor the hematopoietic growth factor(s) produced is known. We show by mRNA analysis that an immortalized line of human endothelial cells constitutively produce granulocyte-macrophage colony-stimulating factor. Furthermore, interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelial cells to produce the same growth factor.