Midkine Signaling in Glioblastoma: A Novel Developmental Drug Target?

Abstract

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is a complicated disease to treat. The current standard therapy includes surgical resection, followed by a combination of radiation and chemotherapy with several drugs. However, resistance and recurrence are quite common, so we continue to investigate more effective treatments both for initial therapy and recurrence by searching novel neglected molecular targets as midkine. This article will review the significance of midkine in therapy for newlydiagnosed and recurrent glioblastomas.