Preparation of four types of coenzyme Q10/γ-cyclodextrin supramolecular complexes and comparison of their pharmaceutical properties

Abstract

In this study, we prepared four kinds of complexes of Coenzyme Q10 (CoQ10) with γ-cyclodextrin (γ-CyD) by the kneading methods and the solubility methods with or without heating, and compared their pharmaceutical properties. Differential scanning calorimetrical curves and powder X-ray diffraction patterns showed that the complexes formed pseudorotaxane-like supramolecular structure, although included free γ-CyD and CoQ10, when prepared by the kneading method and solubility method without heating. At the preparation process, a heating improved the complexation of CoQ10 with γ-CyD in the both methods. The dispersion rate of CoQ10 in water increased in the order of CoQ10 alone≈physical mixture with γ-CyD≪solubility/ heating product