The correlation between hemostatic parameters and mortality rate in patients with non-small cell lung cancer

Abstract

The increasing level of hemostatic parameters and tumor markers were associated with cancer progression and poor prog-nosis, particularly in NSCLC. The objective of this study is to determine whether there was a correlation between hemostatic parameters and mortality rate in patients with NSCLC. This was a prospective ana-lytical study with a pretest-posttest design which included 41 patients with diagnosis of NSCLC. Plasma levels of PT, APTT, TT, D-dimer, and fibrinogen were measured before initiation of chemotherapy and re-measured after 4 cycles or 6 cycles of chemotherapy, based on the clinical condi-tion of patients. Then, patients were fol-lowed up for 1 year to evaluate the mortality rate. The majority of subjects were male (85.4%) with adenocarcinoma (75.6%). There was no significant difference in mean between adenocarcinoma and squamous cell carcinoma (P>0.05). Most patients died after one month of follow up (61%). The parameters which could predict high mortality rate in NSCLC were prolonged PT and the increased of D-dimer with RR>1, although they had not significant in statisti-cal analysis (P>0.05). There is no correlation between hemostatic parameters and mortality rate in patients with NSCLC.