Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction

Abstract

Hydrogen sulfide (H) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H has recently received much interest as a physiological signaling molecule. H is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H is an endogenous neuromodulator and present studies show that physiological concentrations of H enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H in mitochondria have many favorable effects on cytoprotection. © 2012 Wei Guo et al.